Q: Since most samples are injected into QUANTOS unchanged, each measurement generates an overall picture of the sample with no distortions and with all measurable ingredients, including parameters such as pH value. The analysis of the entire sample matrix can also provide numerous qualitative statements about e.g. freshness, bacterial contamination and the organic quality of the sample. The measurement can be described as a digitised sample and contains the information of all molecular components and their secondary information. Only ingredients that are removed during filtration cannot be captured. Unexpected ingredients are always captured too and can be analysed. Analyses on new substances can also be performed subsequently with the available spectrum at any time.
HPLC: Individual classes of ingredients in a sample must be measured separately from each other. Qualitative statements are often based on interactions between ingredients. If they are only measured separately from each other, it is almost impossible to make useful qualitative statements. Parameters such as viscosity etc. must be captured as well using other methods. During a routine analysis, unknown ingredients are a problem because, at best, they are detected as an error. Normally, they are not identified but can have a negative impact on the relevant peaks or affect – or even damage – the column material, rendering it useless for subsequent measurements, without this being noticed.